Here, the current, from 2016, data on swine influenza in US are presented and discussed. The following topics put forward: “Vaccine efficacy of live – attenuated virus, whole – virus inactivated and alphavirus vectored subunit vaccines against antigenically distinct H3N2 swine influenza A viruses”; “Novel reassortant human like H3N2 and H3N1 influenza A viruses detected in pigs as being virulent and antigenically distinct from endemic viruses”; Effect of sow vaccination and maternally – derived antibodies on influenza infection”; “Airborne transmission of highly pathogenic avian influenza virus as risk for swine”; “Evaluation of diagnostic sampling techniques used in the farrowing house to increase sensitivity of detection and sequencing of influenza A virus in swine”; “Lessons learned from highly pathogenic avian influenza (HPAI)”; “Web-based tools and services being developed for producer group specific and large scale swine health monitoring applications”; “Interspecies transmission of influenza A viruses”; “Considerations for vaccines against influenza A viruses in US swine”. The authors, critically evaluated mentioned topics and presented major directions in the current knowledge of swine influenza.