Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage.

AUT.HENDRIKSEN RENE S., MUNK PATRICK, NJAGE PATRICK, VAN BUNNIK BRAM, MCNALLY LUKE…AUT.WASYL DARIUSZ(79.)

Opis bibliograficzny

Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. [AUT.] HENDRIKSEN RENE S., MUNK PATRICK, NJAGE PATRICK, VAN BUNNIK BRAM, MCNALLY LUKE, LUKJANCENK OKSANA, RÖDER TIMO, NIEUWENHUIJSE DAVID, KARLSMOSE PEDERSEN SUSANNE, KJELDGAARD JETTE, KAAS ROLF, LANKEN CONRADSEN CLAUSEN PHILIP THOMAS, KORBINIAN VOGT JOSEF, LEEKITCHAROENPHON PIMLAPAS, VAN DE SCHANS MILOU, ZUIDEMA TINA, DE RODA HUSMAN ANA MARIA, RASMUSSEN SIMON, PETERSEN BENT, BEGO ARTAN, REES CATHERINE, CASSAR SUSAN, COVENTRY KRIS, COLLIGNON PETER, ALLERBERGER FRANZ, RAHUBE TEDDIE, OLIVEIRA GUILHERME, IVANOV IVAN, VUTHY YITH, SOPHEAK THET, YOST CHRISTOPHER, KE CHANGWEN, ZHENG HUANYING, BAISHENG LI, JIAO XIAOYANG, DONADO-GODOY PILAR, COULIBALY KALPY JULIEN, JERGOVIĆ MATIJANA, HRENOVIC JASNA, KARPÍŠKOVÁ RENÁTA, VILLACIS JOSE EDUARDO, LEGESSE MENGISTU, EGUALE TADESSE, HEIKINHEIMO ANNAMARI, MALANIA LILE, NITSCHE ANDREAS, BRINKMANN ANNIKA, SABA COURAGE KOSI SETSOAFIA, KOCSIS BELA, SOLYMOSI NORBERT, THORSTEINSDOTTIR THORUNN R., HATHA ABDULLA MOHAMED, ALEBOUYEH MASOUD, MORRIS DEARBHAILE, CORMICAN MARTIN, O’CONNOR LOUISE, MORAN-GILAD JACOB, ALBA PATRICIA, BATTISTI ANTONIO, SHAKENOVA ZEINEGUL, KIIYUKIA CIIRA, NG’ENO ERIC, RAKA LUL, AVSEJENKO JEĻENA, BĒRZIŅŠ AIVARS, BARTKEVICS VADIMS, PENNY CHRISTIAN, RAJANDAS HERAA, PARIMANNAN SIVACHANDRAN, VELLA HABER MALCOLM, PAL PUSHKAR, JEUNEN GERT-JAN, GEMMELL NEIL, FASHAE KAYODE, HOLMSTAD RUNE, HASAN RUMINA, SHAKOOR SADIA, ZAMUDIO ROJAS MARIA LUZ, WASYL DARIUSZ, BOSEVSKA GOLUBINKA, KOCHUBOVSKI MIHAIL, RADU COJOCARU, GASSAMA AMY, RADOSAVLJEVIC VLADIMIR, WUERTZ STEFAN, ZUNIGA-MONTANEZ ROGELIO, TAY MOON, GAVAČOVÁ DAGMAR, PASTUCHOVA KATARINA, TRUSKA PETER, TRKOV MARIJA, ESTERHUYSE KERNEELS, KEDDY KAREN, CERDÀ-CUÉLLAR MARTA, PATHIRAGE SUJATHA, NORRGREN LEIF, ÖRN STEFAN, LARSSON D. G JOAKIM, VAN DER HEIJDEN TANJA, HOUKA KUMBURU HAPPINESS, SANNEH BAKARY, BIDJADA PAWOU, NJANPOP-LAFOURCADE BERTHE-MARIE, NIKIEMA-PESSINABA SOMTINDA CHRISTELLE, LEVENT BELKIS, MESCHKE JOHN SCOTT, KOREN BECK NICOLA, DANG VAN CHINH, DO PHUC NGUYEN, NGUYEN TRAN DOAN MINH, KWENDA GEOFFREY, TABO DJIM-ADJIM, WESTER ASTRID LOUISE, CUADROS-ORELLANA SARA, AMID CLARA, COCHRANE GUY, SICHERITZ-PONTEN THOMAS, SCHMITT HEIKE, MATHEU ALVAREZ JORGE RAUL, AIDARA-KANE AWA, PAMP SÜNJE, LUND OLE, HALD TINE, WOOLHOUSE MARK, KOOPMANS MARION, VIGRE HÅKAN, PETERSEN THOMAS NORDAHL, AARESTRU FRANK M.. Nature Communications. DOI: 10.1038/s41467-019-08853-3
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Szczegóły publikacji

Źródło:
Nature Communications
Rok:2019
Język:angielski
Charakter formalny:Artykuł w czasopismie
Typ MNiSW/MEiN:inne

Streszczenia

Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.

Linki zewnętrzne

PBN
5ffc28962467f024010b436e
DOI
10.1038/s41467-019-08853-3
Strona WWW
https://www.nature.com/articles/s41467-…

Identyfikatory

ISSN: 2041-1723
BPP ID: (7, 9545) wydawnictwo ciągłe #9545

Metryki

200,00
Punkty MNiSW/MEiN
0
Impact Factor
0
Index Copernicus
0
Punktacja wewnętrzna

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Rekord utworzony:2 kwietnia 2025 01:22
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