As in previous years, the European Food Safety Authority (EFSA), and the European Centre for Disease Prevention and Control (ECDC), published Report on the monitoring of zoonoses and zoonotic agents in the European Union (EU), in 2019. Campylobacteriosis still remains the first, most reported zoonotic disease in humans, in the EU, with 220,682 laboratory confirmed cases, including 715 in Poland. This means, that the trend for confirmed human cases of this disease was stable during years 2015–2019. Poultry meat is probably the most important source of food-borne Campylobacter. Salmonellosis was the second, most commonly recorded zoonosis with 87,923 confirmed human cases (8,373 in Poland), which is was at the a slightly lower level when compared to 2018. Salmonella was identified mainly in fresh poultry meat and products thereof. VTEC infections in humans, with regard to frequency, were the third reported zoonosis in the EU, with a total of 7,775 confirmed infections (14 in Poland), which was less than in the previous year (8,161 cases). Yersiniosis was identified in 7,048 people (196 in Poland), which was slightly less as compared to the previous data (7,204 cases). The number of listeriosis cases moderately increased to 2,621, including 121 people in Poland. However, the mortality rate was high and in the EU 300 persons have died, including 54 in our country. On the other hand, Listeria monocytogenes rarely exceeded the EU food safety limits in ready-to-eat food. The number of Francisella tularensis infections and Q fever cases were 1,280 and 950, respectively. For the first time since 2014, Q fever was identified in Poland (4 cases). Then, in 2019, Brucella and Mycobacterium bovis or M. caprae infected people were identified as 310 and 147 (two and 0 in Poland), respectively. This article aims at the presentation of the Report findings.